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Univ. Prof. <br/> Dr. med. Raimund W. Kinne
Univ. Prof.
Dr. med. Raimund W. Kinne

Telephone:
036691 8-1228


Quality assurance of regenerative tissue replacement materials

Standards for the insertion of the body's own cartilage cell implants

In October 2009, the research group of the Chair of Orthopaedics at the Waldkrankenhaus Eisenberg launched a joint project for quality assurance of regenerative tissue replacement materials: In the next three years, the scientists define standards and norms for the insertion of endogenous cartilage cell implants in this six million Euro project. The research group is led by Prof. Dr. med. Raimund W. Kinne.

Already in 2008, the "Deutsche Gesellschaft für Orthopädie und Orthopädische Chirurgie" launched the new research project with start-up funding of EUR 20,000:  Under the heading "Biomechanical characterisation of tissue engineering", standardised testing procedures and standards were developed which are applied in connection with quality assurance measures for cartilage cell implants.

After the EMEA (European Medicines Agency) issued new directives for the certification of medical products containing human cells, exact testing standards and testing methods for these must now be drawn up in accordance with scientific standards. This is an undertaking which proves to be extremely complex – as the implants should be comprehensively tested before, during and after the implantation with regard to their biomechanical properties or for example with regard to toxicological and pharmacological aspects. 

In close cooperation with scientist and research laboratories from Hanover, Heidelberg, Rosenheim, Mannheim, Munich and Aachen, the Jena/Eisenberg research team will drive this highly inter-disciplinary, large-scale project forward in cooperation with partners from the industry. 72 % of the total funding volume of EUR 6 million is supplied by the BMBF (Bundesministerium für Bildung und Forschung = German Federal Ministry of Education and Research). In addition, the partners from the industry will bear some of the costs.

The patients in particular will benefit when the newly defined standards for the insertion of endogenous cartilage cell implants are available after three years. Throughout the project, new scientific findings appear, which the clinically operating doctors involved in the project can directly use and implement.

In addition to the actual objective, the drafting of testing standards, at the end wide-ranging, new scientific findings are obtained which further improve the medical procedure of regenerative therapy methods for cartilage injuries and considerably extend the service life and functionality of the transplants.


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Prof. Dr. med. Raimund W. Kinne (left) is head of the research group for quality assurance of regenerative tissue replacement materials.

Prof. Dr. med. Raimund W. Kinne (left) is head of the research group for quality assurance of regenerative tissue replacement materials.

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Orthopaedics: Knee disorders
Brief profile

The Chair for Orthopaedics is an internationally recognised clinic for the treatment of orthopaedic disorders of the knee. Every year we treat over a thousand patients with symptoms of wear of the knee joint (gonarthrosis), inflammatory joint disorders (arthritis) or osteonecrosis (bone infarction).

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